RAF Typhoon FGR4s have operated alongside France's air force in a combined operation targeting an underground arms cache in Syria used by the IS group, as stated by the British defence ministry.
The site, located using surveillance, was assessed as housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in central Syria.
"Our aircraft used precision-guided Paveway IV munitions to hit a series of access tunnels down to the facility... preliminary assessments indicate the objective was successfully hit," officials stated.
There was no sign of any civilian impact in the attack conducted Saturday night and every plane involved returned safely, the ministry further stated.
The British jets were assisted by a Voyager refuelling tanker.
The Islamic State group - referred to as Daesh - enforced extremist governance over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This operation underscores the UK's leading role, and determination to operate in unison with our allies, to stamp out any revival of Daesh and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the minister remarked.
British military aircraft have performed surveillance missions over Syria to "deter any attempted resurgence" of IS subsequent to its military defeat at the Baghuz confrontation in the year 2019, the authorities noted.
"I want to thank the personnel of the UK armed forces who took part in this operation for their expertise and their bravery," the Defence Secretary commented. "Including them were numerous British personnel on duty over Christmas and New Year. This operation, to eliminate terrorist threats who pose a risk to our safety, shows how British military are always on standby, throughout the year, ensuring Britain's security at home and powerful internationally."
During December, the US military conducted what it described as a "large-scale strike" targeting IS targets in Syria, after an attack claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The UN estimates IS still boasts roughly 5-7 thousand militants in Syria and Iraq.